EFFECT OF AEROBIC TRAINING AND WALNUT CONSUMPTION ON NESFATIN-1 AND INSULIN RESISTANCE INDEX OF WOMEN TYPE 2 DIABETES

Background: Nesfatin-1 is an adipokine that released by adipose tissue and participated in the regulation of insulin activity and glucose metabolism. The aim of this research is the investigation the effect of aerobic training and walnut consumption on nesfatin-1 and insulin resistance index of women Type 2 diabetes. Methods: 40 women aged 40 to 50  years old with type 2 diabetes after homogenization based on Bruce test were selected through targeted sampling and they were randomly assigned to four groups of training, walnut, training + walnut and control (each group was 10). The 8-week aerobic training was three sessions per week for 16 minutes with 65% of maximal heart rate in the first week, while in the eighth week it reached 30 minutes with 80% of maximal heart rate. The walnut groups each day replaced 25 to 27 grams of walnuts as part of a diet rich in PUFA fatty acids, replacing one third of total dietary fat. 24 hours before the first session and 48 hours after the last session of the protocol, all subjects received blood samples. The inter-subject inter-analysis variance analysis was used. The significance level was considered as P <0.05. Results: In the training groups, weight, body mass index, glucose, insulin and insulin resistance decreased significantly and the maximum oxygen consumption and nesfatin -1 increased significantly(P<0.05). Conclusion: Aerobic training with this intensity and amount can be recommended as auxiliary treatment for type 2 diabetic women. Walnut consumption with this value did not affect the level of blood glucose, insulin resistance index and nesfatin-1 in type 2 diabetic women. It is recommended that high-dose walnuts be used for effective operation.